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Spotlight on FLI1, RUNX1, and platelet dysfunction

A Koneti Rao1

  • 1TEMPLE UNIVERSITY SCHOOL OF MEDICINE.

Blood
|December 17, 2013
PubMed

In this issue of Blood, Stockley et al describe mutations in FLI1 and RUNX1, identified by next-generation sequencing (NGS) studies, in 6 of 13 patients with excessive bleeding and impaired platelet dense granule secretion, and highlight transcription factor (TF) mutations as an important mechanism for inherited platelet dysfunction.

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