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Updated: May 4, 2026

Visualization of HIV-1 Gag Binding to Giant Unilamellar Vesicle GUV Membranes
Published on: July 28, 2016
Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles
Rodrigo Acuña1, Nicolás Cifuentes-Muñoz, Chantal L Márquez
1Molecular Virology Laboratory, Fundación Ciencia & Vida, Santiago, Chile.
Abstract:
How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera.
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