Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracellular calcium-binding proteins: structure and possible functions.

C W Heizmann

    Journal of Cardiovascular Pharmacology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.

    General physiology and biophysics·2008
    Same author

    Pathologies involving the S100 proteins and RAGE.

    Sub-cellular biochemistry·2008
    Same author

    Immunocytochemical localization of S100A1 in mitochondria on cryosections of the rat heart.

    General physiology and biophysics·2007
    Same author

    Interferon-alpha and transforming growth factor-beta co-induce growth inhibition of human tumor cells.

    Cellular and molecular life sciences : CMLS·2006
    Same author

    Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm.

    Neuropathology and applied neurobiology·2005
    Same author

    Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis.

    Journal of inherited metabolic disease·2005

    Calcium-binding proteins with EF-hand structures act as intracellular targets for calcium signaling. This study compares the roles and distribution of key calcium-binding proteins like calmodulin, parvalbumin, and S-100 proteins in various cell types.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Molecular Biology

    Background:

    • Calcium ions (Ca2+) function as critical intracellular second messengers.
    • Specific calcium-binding proteins with EF-hand structures mediate Ca2+ signaling.
    • Diverse families of calcium-binding proteins exist, varying in distribution and function.

    Purpose of the Study:

    • To compare the properties, distribution, and roles of various intracellular calcium-binding proteins.
    • To investigate the functions of calmodulin, parvalbumin, S-100 proteins, and other Ca2+-binding proteins.
    • To elucidate the specific roles of these proteins in muscle, brain, and tumor cells.

    Main Methods:

    • Comparative analysis of protein properties.
    • Examination of protein distribution across different tissues and cell types.

    Related Experiment Videos

  • Functional role assessment in cellular processes.

    • Main Results:

    • Calmodulin is ubiquitously expressed in eukaryotic cells, regulating diverse Ca2+-dependent processes.
    • Parvalbumin, S-100 proteins, vitamin D-dependent Ca2+-binding proteins, and tumor-associated proteins exhibit tissue-specific expression.
    • These specific proteins are involved in specialized functions like Ca2+-buffering and Ca2+-transport within distinct cell types.

    Conclusions:

    • Intracellular calcium-binding proteins exhibit differential expression patterns and specialized functions.
    • Calmodulin serves a general regulatory role, while other EF-hand proteins are involved in specific cellular mechanisms.
    • Understanding these proteins is crucial for comprehending calcium's role in cellular physiology and disease.