Perioperative management of antiplatelet therapy

Area of Science:

• Cardiology
• Pharmacology

Background:

• Cardiovascular events are a leading cause of death globally.
• Platelets play a critical role in the development of these events.
• Antiplatelet medications are vital for preventing thrombotic events, especially after stent placement.

Purpose of the Study:

• To review the pharmacological and pharmacokinetic properties of antiplatelet drugs.
• To examine current literature and guidelines for perioperative antiplatelet management.
• To guide optimal strategies for patients on antiplatelet therapy undergoing surgery.

Main Methods:

• Literature review of older and novel antiplatelet agents.
• Analysis of risk stratification for cardiovascular thrombosis and surgical bleeding.
• Examination of therapeutic pathways for perioperative antiplatelet management.

Main Results:

• Different antiplatelet agents possess distinct pharmacological profiles.
• Patient management involves risk stratification to balance thrombotic and bleeding risks.
• Therapeutic options include continuing, discontinuing, or selectively maintaining antiplatelet agents.

Conclusions:

• Perioperative management of antiplatelet therapy requires careful consideration of individual patient risk.
• Optimizing antiplatelet drug management is essential for surgical patients.
• Evidence-based guidelines inform decisions on managing antiplatelet agents during the perioperative period.