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Eight new peptaibols from sponge-associated Trichoderma atroviride
Irina Panizel, Oded Yarden, Micha Ilan
1Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel. carmeli@post.tau.ac.il.
Marine Drugs
|December 17, 2013
Summary
Researchers discovered new trichorzianines, a type of peptide, from the fungus Trichoderma atroviride. These compounds show antimicrobial activity against Mediterranean bacteria.
Area of Science:
- Marine natural products chemistry
- Fungal secondary metabolites
- Antimicrobial peptide research
Background:
- Axinellid sponges are a source of bioactive compounds.
- Trichoderma species produce peptaibols with diverse biological activities.
- Peptaibols are characterized by a high content of α-aminoisobutyric acid (Aib).
Purpose of the Study:
- To isolate and characterize novel peptaibols from Trichoderma atroviride.
- To investigate the structural features of these peptaibols.
- To evaluate the antimicrobial potential of the isolated compounds.
Main Methods:
- Culturing of Trichoderma atroviride (NF16) from an Axinellid sponge.
- Isolation and purification of peptaibols.
- Structure elucidation using High-Resolution Mass Spectrometry (HRMS), MS/MS, and NMR spectroscopy (1D and 2D).
Main Results:
- Eight new and four known trichorzianines were identified.
- The isolated compounds are 19-residue linear hydrophobic peptides.
- Structural features include an acetylated N-terminus and a C-terminal amino alcohol.
- The new peptaibols demonstrated antimicrobial activity against environmental bacteria.
Conclusions:
- Trichoderma atroviride produces a diverse range of trichorzianines.
- These peptaibols represent a promising class of antimicrobial agents.
- Further research into their mechanism of action and therapeutic potential is warranted.
