Related Experiment Video

Updated: May 4, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K

Inverse correlation between circulating endothelial progenitor cells with CD34+CD133+ and the severity of coronary

Jing Chi1, Xiaojian Hong, Yuehong Wang

  • 1Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.

The American Journal of the Medical Sciences
|December 17, 2013
PubMed

Insights

Endothelial progenitor cell (EPC) levels decrease with increasing atherosclerosis severity. Lower EPC counts, specifically CD34(+)CD133(+) cells, correlate with more extensive coronary artery disease, suggesting EPCs may predict disease progression.

Area of Science:

  • Cardiovascular Research
  • Cell Biology
  • Medical Diagnostics

Background:

  • Endothelial progenitor cells (EPCs) are crucial for vascular health.
  • A decrease in EPC numbers is observed as atherosclerosis develops.
  • CD34(+)CD133(+) cells represent a key population of EPCs.

Purpose of the Study:

  • To compare the number of CD34(+)CD133(+) EPCs with atherosclerosis severity.
  • To evaluate the relationship between EPC levels and the Syntax score in patients with stable angina.

Main Methods:

  • Study included 80 patients with stable angina undergoing coronary angiography.
  • Patients were grouped based on angiography results (normal, single-vessel, multiple-vessel disease).
  • Flow cytometry quantified CD34(+)CD133(+) EPCs in peripheral blood; Syntax score assessed coronary artery disease extent.

Main Results:

  • Log-transformed EPC levels (lgEPC) were significantly lower in single-vessel and multiple-vessel groups compared to the normal group.
  • Multiple-vessel disease showed lower lgEPC levels than single-vessel disease.
  • Linear regression revealed an inverse correlation between lgEPC and Syntax score.

Conclusions:

  • EPC levels may predict the development and severity of atherosclerosis at a cellular level.
  • Reduced EPCs are associated with more advanced coronary artery disease.
  • EPCs might play a protective role against coronary artery disease, acting as a significant risk factor.
Abstract

More Related Videos

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

2.8K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
973
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
948
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495