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Lifetime risk for cardiovascular disease in a Chinese population: the Chinese Multi-Provincial Cohort Study

Ying Wang1, Jing Liu1, Wei Wang1

  • 1Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital-Beijing Institute of Heart, Lung & Blood Vessel Diseases, Beijing, China.

European Journal of Preventive Cardiology
|December 17, 2013
PubMed

Insights

Lifetime cardiovascular disease (CVD) risk is higher in Chinese men than women. Optimizing risk factors significantly reduces lifetime CVD risk, highlighting the importance of early prevention strategies.

Area of Science:

  • Epidemiology
  • Cardiovascular Health
  • Public Health

Background:

  • Lifetime risk estimation for cardiovascular disease (CVD) traditionally relies on Western population data.
  • There is a need to assess CVD lifetime risk and the influence of risk factors specifically within the Chinese population.

Purpose of the Study:

  • To evaluate the lifetime risk of cardiovascular disease (CVD) in the Chinese population.
  • To determine the impact of various risk factors on the lifetime risk of CVD in this demographic.

Main Methods:

  • A prospective, population-based cohort study design was employed.
  • Data from 21,953 participants (aged 35-84) without baseline CVD were analyzed from the Chinese Multi-Provincial Cohort Study (CMCS).
  • The modified Kaplan-Meier method was utilized for lifetime CVD risk calculation.

Main Results:

  • Lifetime CVD risk up to age 80 for 35-year-old men and women was 24.4% and 20.2%, respectively.
  • Individuals with an optimal risk factor profile exhibited a significantly lower lifetime risk, mitigating aging effects.
  • Conversely, those with two or more high-risk factors faced a substantially elevated lifetime risk (men: 51.1%, women: 38.6% by age 80).

Conclusions:

  • The cumulative status of major CVD risk factors is a key determinant of long-term cardiovascular health and disease risk in China.
  • Aggressive, early-stage prevention focusing on optimizing all risk factors is crucial for future CVD prevention efforts.
  • Findings underscore the need for culturally specific CVD risk assessment and intervention strategies.
Abstract

Keywords:
Cardiovascular diseaseslifetime riskrisk factors

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