Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inflammatory syndrome and changes in plasma proteins].

J Romette, J di Costanzo-Dufetel, M Charrel

    Pathologie-Biologie
    |November 1, 1986
    PubMed
    Summary

    Inflammation involves a biological response to injury, marked by specific proteins. Measuring high-turnover C-reactive protein alongside low-turnover proteins aids in detecting inflammation and assessing treatment effectiveness.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A low budget luminometer for sensitive chemiluminescent immunoassays.

    Journal of immunological methods·2000
    Same author

    [Lupus and macrocreatine phosphokinase induced by mesalazine: a case report].

    La Revue de medecine interne·2000
    Same author

    3D imaging of the 58 kDa cell binding subunit of the Helicobacter pylori cytotoxin.

    Journal of molecular biology·1999
    Same author

    Characterisation of a monoclonal antibody and its use to purify the cytotoxin of Helicobacter pylori.

    FEMS microbiology letters·1998
    Same author

    Influence of photoisomers in bilirubin determinations on Kodak Ektachem and Hitachi analysers in neonatal specimens study of the contribution of structural and configurational isomers.

    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies·1995
    Same author

    Isolated rat hepatocyte metabolism is affected by chronic renal failure.

    Kidney international·1995

    Area of Science:

    • Biochemistry and Immunology
    • Cell Biology

    Context:

    • Inflammation is a complex biological response to injury, clinically presenting with symptoms like fever and elevated sedimentation rate.
    • Biological markers, including inflammatory plasma proteins, are crucial for diagnosing and monitoring inflammatory conditions.

    Purpose:

    • To elucidate the role of Acute Phase Reactant Proteins in the inflammatory process.
    • To highlight the diagnostic utility of specific protein combinations in identifying inflammation and evaluating therapeutic response.

    Summary:

    • Inflammation triggers hepatocytes and macrophages to release Acute Phase Reactant Proteins (APRPs).
    • Interleukin I, released at inflammation sites, induces muscle proteolysis and hepatic amino acid uptake for APRP synthesis.
    • A combination of high-turnover (e.g., C-reactive protein) and low-turnover APRPs (e.g., orosomucoid, haptoglobin) is valuable for detecting inflammation and assessing treatment efficacy.

    Impact:

    • Provides a basis for understanding the biochemical mechanisms underlying inflammation.
    • Establishes the clinical significance of specific APRP combinations for early diagnosis of neonatal bacterial infections and myocardial infarction.
    • Supports the development of targeted diagnostic and therapeutic strategies for inflammatory diseases.

    Related Experiment Videos