Related Experiment Video
Updated: May 4, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
Published on: July 19, 2011
Citrate anticoagulation for continuous renal replacement therapy in small children
Jolanta Soltysiak1, Alfred Warzywoda, Bartłomiej Kociński
1Department of Pediatric Cardiology and Nephrology, Poznan University of Medical Sciences, Poznan, Poland, jsoltysiak1@gmail.com.
Regional citrate anticoagulation (RCA) is safe and effective for critically ill children undergoing continuous renal replacement therapy (CRRT). RCA demonstrated superior circuit longevity and reduced clotting compared to heparin anticoagulation (HA).
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Renal Replacement Therapy
Background:
- Continuous renal replacement therapy (CRRT) requires effective anticoagulation to prevent circuit clotting.
- Regional citrate anticoagulation (RCA) is an alternative to heparin anticoagulation (HA) for CRRT.
Purpose of the Study:
- To compare the outcomes and complications of RCA-CRRT versus HA-CRRT in critically ill children.
- To evaluate the safety and efficacy of RCA in pediatric CRRT.
Main Methods:
- Retrospective review of 30 critically ill children (16 RCA-CRRT, 14 HA-CRRT) undergoing at least 24 hours of CRRT.
- Utilized a commercially available pre-dilution citrate solution for RCA-CRRT.
Main Results:
- RCA-CRRT showed significantly higher circuit lifetime (58.04 h vs. 37.64 h) and reduced circuit clotting (11.63% vs. 34.15%) compared to HA-CRRT.
- While RCA-CRRT had more electrolyte disturbances, it was associated with higher survival rates at discharge (37.5% vs. 14.3%).
Conclusions:
- Regional citrate anticoagulation (RCA) is safe and effective for low-body-weight, critically ill children requiring CRRT.
- RCA offers improved circuit lifespan and reduced clotting compared to heparin anticoagulation (HA) in this pediatric population.
More Related Videos
08:44Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
Published on: September 1, 2016
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Related Concept Videos
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Acute Kidney Injury V: Interprofessional Care
Chronic Kidney Disease III: Interprofessional Care
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Cardiac Catheterization I: Pre-Procedure Overview