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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Pharmacogenomics: Identification of New Drug Targets01:29

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Related Experiment Video

Updated: May 4, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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Transcriptome network analysis reveals potential candidate genes for ankylosing spondylitis.

Z-Q Zhu1, J-S Tang, X-J Cao

  • 1Department of Orthopaedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, JiangSu Province, China. xiaojiancao@gmail.com.

European Review for Medical and Pharmacological Sciences
|December 17, 2013
PubMed
Summary

This study identifies novel genes and pathways involved in ankylosing spondylitis (AS) progression using transcriptome network analysis. The findings highlight potential new targets for developing effective treatments for this chronic inflammatory disease.

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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Area of Science:

  • Immunology
  • Genetics
  • Bioinformatics

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease characterized by spinal pain and potential immobility.
  • Identifying novel therapeutic targets is crucial for managing AS progression.

Purpose of the Study:

  • To identify potential genes and construct a regulatory network associated with ankylosing spondylitis (AS).
  • To explore new therapeutic targets for AS.

Main Methods:

  • Utilized the GSE11886 dataset for transcriptome analysis.
  • Constructed a gene regulation network to identify key genes and pathways in AS.

Main Results:

  • Identified known AS-related genes (e.g., NFKB1, STAT1) and novel candidate genes (e.g., BXDC5, EGFR).
  • Highlighted significant pathways including antigen processing and presentation and cytokine-cytokine receptor interaction.
  • Observed potential roles for apoptosis and systemic lupus erythematosus pathways in AS progression.

Conclusions:

  • Transcriptome network analysis effectively identifies candidate genes for AS.
  • The study provides a foundation for further research into AS pathogenesis and treatment development.