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The Lund concept for severe traumatic brain injury
Dario Muzevic1, Bruno Splavski
1Department of Neurosurgery, School of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, Osijek, Croatia, 31 000.
The Cochrane Database of Systematic Reviews
|December 17, 2013
Summary
Current research found no evidence supporting the Lund concept for severe traumatic brain injury (TBI) management. This alternative approach, focusing on microvascular pressures, was not found to be superior to conventional treatments like intracranial pressure (ICP) or cerebral perfusion pressure (CPP) targeted therapies.
Area of Science:
- Neuroscience
- Critical Care Medicine
- Trauma Surgery
Background:
- Severe traumatic brain injury (TBI) is a major cause of death and disability.
- Current TBI management focuses on preventing secondary brain ischemia by managing intracranial pressure (ICP) and cerebral perfusion pressure (CPP).
- The Lund concept offers an alternative by targeting microvascular pressures.
Purpose of the Study:
- To evaluate the efficacy of the Lund concept compared to conventional TBI treatment strategies.
- The study aimed to assess its role against ICP-targeted, CPP-targeted, and other therapeutic approaches.
Main Methods:
- A systematic review was conducted using multiple databases including Cochrane, MEDLINE, EMBASE, CINAHL, and Web of Science.
- Inclusion criteria focused on randomized controlled trials (RCTs) investigating the Lund concept in TBI patients.
- Study selection and data extraction were performed independently by two reviewers.
Main Results:
- No studies met the inclusion criteria for this systematic review.
- Consequently, no randomized controlled trials were identified to assess the Lund concept's efficacy.
Conclusions:
- There is currently a lack of scientific evidence to support the Lund concept as a preferred treatment for severe traumatic brain injury.
- Further research is needed to establish its potential benefits or drawbacks compared to existing therapies.
