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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

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The prognostic value of arterial stiffness in systolic heart failure

Serafettin Demir1, Onur Akpınar, Oguz Akkus

  • 1Department of Cardiology, Adana State Hospital, Adana, Turkey. demirkardiyoloji@hotmail.com.

Cardiology Journal
|December 17, 2013
PubMed

Insights

Arterial stiffness, measured by augmentation index and pulse wave velocity, significantly predicts mortality in advanced heart failure patients. This simple measurement aids in risk stratification for these individuals.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Physiology

Background:

  • Increased arterial stiffness is a recognized predictor of mortality.
  • Advanced heart failure patients often exhibit heightened arterial stiffness.

Purpose of the Study:

  • To evaluate the prognostic value of arterial stiffness measurements in predicting mortality in advanced heart failure.
  • To assess the relationship between arterial stiffness and mortality over an 18-month follow-up period.

Main Methods:

  • Followed 98 patients with advanced heart failure (NYHA class III-IV, LVEF ≤ 35%).
  • Measured arterial stiffness using augmentation index (Aix) and pulse wave propagation velocity (PWV) via arteriography.
  • Analyzed mortality data over an 18-month period.

Main Results:

  • Both Aix and PWV independently predicted mortality (p=0.013, p=0.025).
  • Specific cutoff values for Aix (-14.33) and PWV (11.06) demonstrated high sensitivity and specificity for mortality prediction.
  • Left ventricular ejection fraction and B-type natriuretic peptide also independently predicted mortality.

Conclusions:

  • Arterial stiffness measurement is a valuable, cost-effective tool for mortality prediction in advanced heart failure.
  • Aix and PWV provide crucial prognostic information beyond traditional markers.
Abstract

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