Related Experiment Video
Updated: May 4, 2026
10:37
Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
9.2K
Intrathecal therapy for chronic pain: current trends and future needs
Salim M Hayek1, Michael C Hanes
1Department of Anesthesiology, Case Western Reserve University, Cleveland, OH, 44106, USA, salim.hayek@uhhospitals.org.
Current Pain and Headache Reports
|December 17, 2013
Summary
Intrathecal drug delivery systems (IDDS) offer an effective solution for chronic pain management. However, challenges like complexity and limited studies hinder wider adoption of this advanced therapy.
Area of Science:
- Pain Management
- Neurosurgery
- Pharmacology
Background:
- Chronic pain management presents significant challenges for healthcare providers.
- Intrathecal drug delivery systems (IDDS) are an effective option for pain intractable to standard medical treatments.
- Current utilization of IDDS may be limited by complexity and reimbursement issues.
Purpose of the Study:
- To provide a comprehensive review of factors influencing successful intrathecal drug delivery.
- To emphasize the application of IDDS in managing non-cancer chronic pain.
Main Methods:
- Literature review focusing on determinants of successful intrathecal drug delivery.
- Analysis of existing evidence regarding IDDS in non-cancer pain management.
Main Results:
- Clinical utility of IDDS is constrained by a lack of high-quality, randomized controlled trials.
- Physician knowledge regarding intrathecal pharmacodynamics and pharmacokinetics needs enhancement.
- Further research into IDDS and novel drug delivery modalities is essential.
Conclusions:
- Optimizing IDDS requires addressing challenges in clinical research, physician education, and reimbursement.
- IDDS hold significant potential for improving outcomes in non-cancer chronic pain patients.
- Continued research and improved understanding are key to expanding the role of IDDS in pain management.
Related Concept Videos
01:29Drug Delivery: Parenteral Route
2.8K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
2.8K
01:25Analgesia and Pain Management
3.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.3K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
2.0K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
2.0K