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Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial

Yong Un Kang1, Min Jee Kim, Joon Seok Choi

  • 1Department of Internal Medicine, Chonnam National University Medical School, 42 Jebong-ro, Gwangju 501-757, Korea. skimw@chonnam.ac.kr.

Yonsei Medical Journal
|December 17, 2013
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) and renal dysfunction worsen outcomes for acute myocardial infarction (AMI) patients. Combined, these factors significantly increase major adverse cardiac events (MACE) and mortality risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Acute myocardial infarction (AMI) is a leading cause of cardiovascular mortality.
  • Biomarkers like high-sensitivity C-reactive protein (hs-CRP) and renal function are crucial for risk stratification.
  • Understanding their combined impact is vital for improving patient outcomes.

Purpose of the Study:

  • To investigate the impact of hs-CRP and renal dysfunction on clinical outcomes in AMI patients.
  • To assess the association between hs-CRP levels, estimated glomerular filtration rate (eGFR), and major adverse cardiac events (MACE).

Main Methods:

  • Retrospective cohort study of 8332 AMI patients.
  • Patients categorized into four groups based on eGFR (≥60 mL·min(-1)·1.73 m(-2) vs. <60) and hs-CRP levels (≤2.0 mg/dL vs. >2.0 mg/dL).
  • One-year follow-up to compare MACE rates.

Main Results:

  • A graded association was observed between increased MACE rates and higher hs-CRP/renal dysfunction.
  • Group IV (renal dysfunction with high hs-CRP) had the highest MACE rate (30.1%).
  • Cox proportional hazards model showed significantly increased 12-month mortality in patients with high hs-CRP and/or renal dysfunction compared to the low-risk group.

Conclusions:

  • Elevated hs-CRP, particularly when combined with renal dysfunction, is linked to MACE in AMI patients.
  • These factors indicate a poor prognosis and increased mortality risk.
  • Risk stratification using hs-CRP and renal function is essential for AMI management.
Abstract

Keywords:
C-reactive proteinglomerular filtration ratemyocardial infarction

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