Hemoglobin E disorder: Newborn screening program

Area of Science:

• Medical Genetics
• Hematology
• Public Health

Background:

• Hemoglobin E (Hb E) disorder is a prevalent hemoglobinopathy globally, with highest incidence in Southeast Asia.
• Screening for Hb E disorder is a significant public health policy in numerous countries.
• Newborn screening for Hb E disorder is a critical aspect of pediatric genetics.

Purpose of the Study:

• To review important laboratory tests for screening Hemoglobin E (Hb E) disorder in newborns.
• To provide an overview of current screening methodologies for Hb E disorder in pediatric populations.

Main Methods:

• This review discusses various laboratory diagnostic methods.
• Focus is placed on tests suitable for newborn screening programs.

Main Results:

• The review identifies and describes key laboratory tests essential for accurate Hb E disorder screening.
• Emphasis is placed on the utility and importance of these tests in early detection.

Conclusions:

• Effective laboratory testing is fundamental for successful newborn screening programs for Hb E disorder.
• Early identification through screening aids in managing this significant hemoglobinopathy.