Related Experiment Video
Updated: May 4, 2026
10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
1.9K
Dendritic cell-targeted approaches to modulate immune dysfunction in the tumor microenvironment.
1Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, NY , USA.
Frontiers in Immunology
|December 17, 2013
Summary
Dendritic cell (DC) cancer therapies show promise but face challenges. Optimizing DC vaccine potency and targeting the tumor microenvironment (TME) may overcome immune suppression for durable cancer immunity.
Area of Science:
- Immunology
- Oncology
- Cancer Therapy
Background:
- Significant advancements in dendritic cell (DC) biology have occurred.
- DC-based cancer therapies are gaining attention.
- The clinical efficacy of current DC vaccines is not yet established.
Purpose of the Study:
- To explore strategies for enhancing DC vaccine potency.
- To investigate methods for overcoming immune suppression in the tumor microenvironment (TME).
- To identify promising avenues for successful cancer immunotherapies.
Main Methods:
- Review of recent progress in DC biology.
- Analysis of challenges in DC-based cancer vaccine development.
- Exploration of novel therapeutic strategies targeting the TME.
Main Results:
- Suboptimal DC generation and TME-mediated immune suppression limit current DC vaccine success.
- Optimizing DC vaccine potency is crucial.
- Targeting the TME can overcome immune dysfunction.
Conclusions:
- Combining optimized DC vaccines with TME-targeting therapies offers potential for durable, tumor-specific immunity.
- Novel interventions targeting the TME are promising for cancer immunotherapy.
- Further research is needed to establish the clinical impact of DC-based vaccines.
Related Concept Videos
01:27Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
02:17The Tumor Microenvironment
6.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.3K
01:27Cytotoxic T Cells-mediated Immune Response
7.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.0K
02:57Targeted Cancer Therapies
7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.0K