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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits
Suman Ghosal1, Shaoli Das, Rituparno Sen
1Computational Biology Group, Theory Department, Indian Association for the Cultivation of Science Kolkata, India.
Frontiers in Genetics
|December 17, 2013
Summary
Circular RNAs (circRNAs) regulate gene expression by sequestering microRNAs (miRNAs). This study identifies potential associations between circRNAs and human diseases, creating a valuable resource for further research.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Circular RNAs (circRNAs) are emerging regulators of post-transcriptional gene expression.
- circRNAs play a role in fine-tuning miRNA-mediated gene regulation by acting as miRNA sponges.
- Interactions between circRNAs and disease-associated miRNAs suggest a role for circRNAs in disease pathogenesis.
Purpose of the Study:
- To investigate the potential association of circular RNAs (circRNAs) with human diseases.
- To identify interactions between circRNAs and disease-associated miRNAs.
- To create a comprehensive database of disease-circRNA associations.
Main Methods:
- Network analysis of miRNA-circRNA interactions for individual diseases.
- Gene Ontology (GO) enrichment analysis of protein-coding genes in miRNA-circRNA interactomes.
- Mapping disease-associated SNPs to circRNA loci and identifying Argonaute (Ago) interaction sites.
Main Results:
- Identification of potential circRNA-disease associations through miRNA interactions and SNP mapping.
- Construction of a miRNA-circRNA interactome network for various diseases.
- Development of Circ2Traits, a comprehensive database of human disease-circRNA associations.
Conclusions:
- Circular RNAs are implicated in human disease regulation through their interactions with miRNAs.
- The Circ2Traits database provides a valuable resource for understanding circRNA's role in diseases.
- Further research into circRNA-disease links can advance diagnostics and therapeutics.
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