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Published on: August 11, 2015
Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial
Ehsan Ullah Syed1, Mohammad Wasay, Safia Awan
1Department of Psychiatry Penn State Milton S Hershey Medical Center Penn State College of Medicine, Hershey, PA, USA.
Background/Objective:
Recent literature has identified links between vitamin B12 deficiency and depression.We compared the clinical response of SSRI-monotherapy with that of B12-augmentation in a sample of depressed patients with low normal B12 levels who responded inadequately to the first trial with the SSRIs.
Methods:
Patients with depression and low normal B12 levels were randomized to a control arm (antidepressant only) or treatment arm (antidepressants and injectable vitamin B12 supplementation).
Results:
A total of 199 depressed patients were screened. Out of 73 patients with low normal B12 levels 34 (47%) were randomized to the treatment group while 39 (53%) were randomized to the control arm. At three months follow up 100% of the treatment group showed at least a 20% reduction in HAM-D score, while only 69% in the control arm showed at least a 20% reduction in HAM-D score (p<0.001). The findings remained significant after adjusting for baseline HAM-D score (p=0.001).
Conclusion:
Vitamin B12 supplementation with antidepressants significantly improved depressive symptoms in our cohort.
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