Related Experiment Video

Updated: May 4, 2026

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
08:16

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

Published on: February 26, 2019

7.9K

Cytomegalovirus enteritis with jejunal perforation in a patient with endometrial adenocarcinoma

Young Jin Jun1, Jongmin Sim, Hye In Ahn

  • 1Young Jin Jun, Jongmin Sim, Hye In Ahn, Hulin Han, Hyunsung Kim, Kijong Yi, Abdul Rehman, Se Min Jang, Kiseok Jang, Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, South Korea.

World Journal of Clinical Cases
|December 17, 2013
PubMed

Insights

Cytomegalovirus (CMV) infection rarely affects the small bowel. This case highlights CMV enteritis causing jejunal perforation in an immunocompetent patient after cancer treatment.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Oncology

Background:

  • Cytomegalovirus (CMV) gastrointestinal infections typically occur in immunocompromised individuals.
  • While the entire GI tract can be affected, small bowel involvement is uncommon.

Observation:

  • A 53-year-old woman, 8 years post-chemoradiation for endometrial cancer, presented with abdominal pain, diarrhea, and vomiting.
  • CT scan revealed free air, indicating perforation, and jejunal inflammation with purulent exudates.
  • Surgical resection showed a large ulcerative lesion in the jejunum.

Findings:

  • Microscopic examination revealed diffuse ulcerative changes with granulation tissue.
  • Atypical endothelial cells and fibroblasts with characteristic intranuclear/intracytoplasmic inclusion bodies were identified.
  • Immunohistochemistry confirmed CMV infection in the affected jejunal tissue.

Implications:

  • This case underscores the possibility of CMV enteritis with jejunal perforation in patients with a history of cancer therapy, even without overt immunodeficiency.
  • It emphasizes the importance of considering CMV in the differential diagnosis of small bowel complications post-chemotherapy.
  • Early recognition and treatment of CMV enteritis are crucial to prevent severe complications like perforation.
Keywords:
CytomegalovirusEnteritisJejunumPerforation

More Related Videos

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

7.8K
Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection11:13

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Published on: March 28, 2012

23.6K

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
844
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.2K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.0K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
46