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Sulfadiazine modified CS/HA PEC destined to wound dressing
Lenuţa Profire1, D Pieptu, Raluca Petronela Dumitriu
1Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi.
Aim:
To present the research results concerning enhanced antimicrobial and release properties of the chitosan derivative with sulfadiazine/hyaluronic acid polyelectrolyte complex (PEC) hydrogel.
Material And Methods:
The PECs have been prepared from chitosan of different molecular weight, sulfadiazine chitosan derivative and sodium hyaluronate. The complex structure was assessed by FT-IR spectroscopic method and swelling capacity was followed by weighing measurements.
Results:
It has been establish that chitosan derivative influenced both PEC properties and swelling capacity.
Conclusions:
Incorporation in PEC of the sulfadiazine chitosan is a new way to combine bacteriostatic effect of chitosan with that of sulfadiazine, to control properties, antimicrobial activity in the treatment of the wound.
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