Related Experiment Video
Updated: May 4, 2026
04:30
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
3.0K
Low circulating monocyte count is associated with severe aortic valve stenosis
Shmuel Schwartzenberg1, Valery Meledin1, Liaz Zilberman1
1Heart Institute, Kaplan Medical Center, Rehovot, affiliated with Hebrew University-Hadassah Medical School, Jerusalem, Israel.
The Israel Medical Association Journal : IMAJ
|December 18, 2013
Summary
Severe aortic stenosis (AS) is linked to lower monocyte counts, suggesting a role for these cells in AS development. This study explored white blood cell differentials in AS progression.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Pathophysiology
Background:
- Aortic stenosis (AS) pathophysiology involves inflammation, including immune cell infiltration and lipid deposition in the aortic valve (AV).
- Understanding the role of specific immune cells, like monocytes, may elucidate AS pathogenesis.
Purpose of the Study:
- To investigate the relationship between white blood cell (WBC) differential counts and the presence and progression of aortic stenosis (AS).
Main Methods:
- Retrospective analysis of 150 patients with AS who had serial echocardiograms.
- Correlation of average WBC differential counts from the prior 3 years with AS severity indices.
Main Results:
- Monocyte counts progressively decreased with increasing AS severity, notably between mild and severe groups.
- A significant negative correlation was observed between monocyte count and AS severity (AV peak velocity, peak/mean gradients).
- No correlation was found between WBC differentials and the annual rate of AS progression.
Conclusions:
- Severe AS is associated with a reduced total monocyte count.
- These findings suggest monocytes may play a role in the underlying mechanisms of aortic stenosis pathogenesis.
Related Concept Videos
01:22Mitral Stenosis I: Introduction
1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
557
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.2K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
01:27Mitral Stenosis IV: Nursing Management
422
A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
422
01:15Aortic Regurgitation I: Introduction
1.6K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K
01:26Mitral Stenosis III: Medical Management
535
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
535