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Updated: May 4, 2026
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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
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Group B Streptococci investigation in pre-term labors
Elahe Zarean Seyyed1, Ehsan Toossi1, Akram Jalalvand1
1Isfahan University of Medical Sciences, Isfahan, Iran.
Medical Archives (Sarajevo, Bosnia and Herzegovina)
|December 18, 2013
Summary
Maternal Group B Streptococcus (GBS) colonization is significantly more common in women experiencing pre-term labor compared to those with full-term deliveries. Further research is needed to understand GBS
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Perinatal Health
Background:
- Pre-term delivery is a leading cause of perinatal mortality and morbidity.
- Maternal Group B Streptococcus (GBS) colonization is a potential contributing factor to pre-term birth.
Purpose of the Study:
- To investigate the association between maternal GBS colonization and pre-term delivery.
- To compare GBS colonization rates in women with pre-term labor versus those with term deliveries.
Main Methods:
- A case-control study was conducted with 200 women in pre-term labor (cases) and 200 women in term pregnancy (controls).
- Maternal GBS colonization was assessed through vaginal and rectal samples.
- Data were collected between March 2010 and May 2011 at two referral university hospitals in Iran.
Main Results:
- Maternal age and gravidity were similar between case and control groups.
- Higher levels of education and gestational age were observed in the control group.
- GBS colonization was significantly higher in the pre-term labor group (39.1% vaginal, 36.4% rectal) compared to the term delivery group (20.2% vaginal, 16.9% rectal).
- Antibiotic use during pregnancy was more frequent in the pre-term labor group.
Conclusions:
- Maternal GBS colonization is statistically more prevalent in pre-term labors.
- Further large-scale observational studies are required to elucidate the mechanism of GBS's impact on pregnancy and pre-term delivery.
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