[Pathomorphology of periventricular leukomalacia and other white matter lesions in infants]

The paper describes white matter lesions that differ from periventricular leukomalacia (PVL), such as diffuse leukomalacia (DL) and telencephalic gliosis (TG). There are three types of cerebral leukomalacias: PVL, DL, and subcortical leukomalacia. The morphological differences between PVL and DL are considered. The diffuse form of PVL is described. It is pointed out that colliquation PVL foci frequently occur in infants with birth weight less than 1500 g. There are data on the morphology of TG in which generalized and occasionally large-focal astrogliosis develops in the cerebral hemispheric white matter. It is suggested that it is inexpedient to identify the focal and diffuse components of PVL. The immunihistochemical findings led to the conclusion that PVL, DL, and TG did not result from the direct effects of pathogens of inherited infections on brain tissue.