Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15
Xiachang Wang1, Sherif I Elshahawi, Khaled A Shaaban
1Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536, United States.
Abstract:
The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Production of Antibiotics
Clinical Significance of Antibiotic Resistance


