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Evolution of MRI changes in Rasmussen's encephalitis

K Pradeep1, S Sinha, J Saini

  • 1Department of Neurology, National Institute of Mental Health and NeuroSciences (NIMHANS), Bangalore, India.

Acta Neurologica Scandinavica
|December 18, 2013
PubMed
Abstract

Insights

MRI findings in Rasmussen's encephalitis (RE) show progressive unihemispheric atrophy, particularly in the perisylvian region. Serial MRI changes can help monitor disease progression and serve as a surrogate marker.

Area of Science:

  • Neurology
  • Radiology
  • Pediatric Neurology

Background:

  • Rasmussen's encephalitis (RE) is a rare, chronic inflammatory neurological disease affecting one cerebral hemisphere.
  • Early and accurate diagnosis is crucial for managing the disease and predicting outcomes.

Purpose of the Study:

  • To analyze Magnetic Resonance Imaging (MRI) findings in patients with Rasmussen's encephalitis.
  • To evaluate serial MRI changes and correlate them with clinical features of the disease.

Main Methods:

  • Retrospective review of 40 brain MRIs from 16 patients diagnosed with RE based on European consensus criteria.
  • Analysis of demographical, clinical, and MRI observations, including serial imaging in 11 patients.

Main Results:

  • All patients exhibited unihemispheric focal cortical atrophy, predominantly in the perisylvian region.
  • Common findings included white matter signal changes and ipsilateral atrophy/signal alterations in the caudate and putamen.
  • Serial MRIs demonstrated progressive cerebral atrophy and a trend towards increased MRI staging.

Conclusions:

  • Pattern recognition of MRI findings, including progressive focal cortical atrophy and specific signal changes, can serve as a surrogate marker for Rasmussen's encephalitis.
  • Serial MRI changes are valuable for understanding and monitoring disease progression in RE.
Keywords:
Rasmussen's encephalitisepilepsia partialis continuaepilepsymagnetic resonance imaging

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