Severity of coronary artery disease and echocardiographic parameters of ventricular diastolic function

Area of Science:

• Cardiology
• Cardiovascular Research
• Echocardiography

Background:

• Coronary artery disease (CAD) is a major cause of cardiovascular morbidity.
• Left ventricular (LV) diastolic dysfunction can occur in CAD patients.
• The relationship between CAD severity and LV diastolic function in stable CAD with preserved ejection fraction requires further investigation.

Purpose of the Study:

• To investigate the association between the severity of coronary artery disease (CAD) and left ventricular (LV) diastolic function.
• To assess diastolic function in patients with stable CAD and normal LV ejection fraction.
• To determine if CAD severity, quantified by SYNTAX Score (SS) and Gensini Score (GS), correlates with LV diastolic impairment.

Main Methods:

• Sixty patients with stable CAD were enrolled.
• Coronary angiography data were used to calculate SYNTAX Score (SS) and Gensini Score (GS).
• Echocardiographic examinations were performed to assess LV diastolic function.

Main Results:

• Patients were stratified into four groups based on median SS and GS.
• LV diastolic function impairment was observed in a high percentage of patients across all groups (75.9%–87.1%).
• No significant differences in clinical or echocardiographic findings were noted between SS and GS groups, indicating no clear correlation with disease severity.

Conclusions:

• Diastolic function did not show impairment related to the severity of CAD in patients diagnosed with stable CAD.
• The study suggests that LV diastolic function may not be directly influenced by CAD severity in this patient cohort.
• Further research is needed to fully elucidate the complex interplay between CAD severity and diastolic function.