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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Thermal Ablation for the Treatment of Abdominal Tumors
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Cancer immunotherapy using tumor cryoablation.

Abhinav Sidana1

  • 1Division of Urology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Suite 2513, Cincinnati, OH 45229, USA. abhinavsidana01@gmail.com.

Immunotherapy
|December 18, 2013
PubMed
Summary
This summary is machine-generated.

Cryoablation therapy can stimulate a systemic antitumor immune response. Combining cryoablation with immunotherapy agents may enhance its effectiveness against metastatic cancers.

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Area of Science:

  • Immunology
  • Oncology
  • Cryoablation Therapy

Background:

  • Cryoablation is a growing treatment for localized and metastatic cancers.
  • Clinical observations and animal studies suggest cryoablation induces systemic antitumor immunity.
  • Enhancing this immune response is key for effective cancer immunotherapy.

Purpose of the Study:

  • To review evidence on cryoablation-induced antitumor immune responses.
  • To discuss mechanisms underlying this immune stimulation.
  • To explore combination strategies with immunotherapy for metastatic disease.

Main Methods:

  • Review of preclinical data.
  • Analysis of clinical evidence.
  • Discussion of immunomodulatory agents and cryoimmunotherapy.

Main Results:

  • Cryoablation is confirmed to induce systemic antitumor immune responses.
  • Mechanisms of immune activation by cryoablation are elucidated.
  • Combination of cryoablation with immunotherapy shows potential for metastatic cancer treatment.

Conclusions:

  • Cryoablation can be a powerful tool in cancer immunotherapy.
  • Combining cryoablation with other immunomodulatory agents is a promising strategy.
  • Cryoimmunotherapy holds potential for managing metastatic cancer progression.