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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Marjolin's ulcer (MU) is a rare, potentially fatal malignancy developing in scars.
  • It typically arises after a significant latency period following the initial injury.

Purpose of the Study:

  • To investigate the characteristics of Marjolin's ulcer patients.
  • To emphasize the role of the latency period in MU prevention and early treatment.

Main Methods:

  • Retrospective review of 17 Marjolin's ulcer patients undergoing surgery between June 2005 and December 2011.
  • Data collected included injury etiology, latency period, ulceration history, and patient outcomes.

Main Results:

  • Marjolin's ulcer incidence was 0.7% among patients with existing scars; burns and trauma were common causes.
  • The mean latency period was 29 years, with a mean post-ulceration period of 7 years.
  • Younger age at injury correlated with longer latency periods (r=-0.8, P<0.01).

Conclusions:

  • Latency periods vary, with younger patients experiencing longer ones.
  • Chronic scars and unhealed ulcers are primary sources of Marjolin's ulcer.
  • Close surveillance during the latency period may enable MU prevention.