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Published on: October 4, 2024
[Cortical spreading depolarization phenomena in patients with traumatic and ischemic brain injuries. Results of a
M Sueiras1, J Sahuquillo2, B García-López3
1Servicio de Neurofisiología, Hospital Universitario Vall d'Hebron, Barcelona, España; Unidad de Investigación de Neurotraumatología y Neurocirugía (UNINN), Hospital Universitario Vall d'Hebron, Institut Fundació de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
Objectives:
To determine the frequency and duration of cortical spreading depolarization (CSD) and CSD-like episodes in patients with traumatic brain injury (TBI) and malignant middle cerebral artery infarction (MMCAI) requiring craniotomy.
Design:
A descriptive observational study was carried out during 19 months.
Setting:
Neurocritical patients.
Patients:
Sixteen patients were included: 9 with MMCAI and 7 with moderate or severe TBI, requiring surgical treatment.
Interventions:
A 6-electrode subdural electrocorticographic (ECoG) strip was placed onto the perilesional cortex.
Main Variables Of Interest:
An analysis was made of the time profile and the number and duration of CSD and CSD-like episodes recorded from the ECoGs.
Results:
Of the 16 patients enrolled, 9 presented episodes of CSD or CSD-like phenomena, of highly variable frequency and duration.
Conclusions:
Episodes of CSD and CSD-like phenomena are frequently detected in the ischemic penumbra and/or traumatic cortical regions of patients with MMCAI who require decompressive craniectomy or of patients with contusional TBI.
