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Updated: May 4, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla
Siew-Huah Lim1, Yun-Yee Low1, Saravana Kumar Sinniah2
1Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract:
A total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The structure and relative configurations of these alkaloids were established using NMR, MS and in several instances, confirmed by X-ray diffraction analysis. Six of these alkaloids were effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells.
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