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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Metabolic syndrome and coronary artery calcification: a community-based natural population study
Hui-Li Cao1, Xiong-Biao Chen1, Jin-Guo Lu1
1Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Insights
Metabolic syndrome (MetS) significantly increases the risk of coronary artery calcification (CAC) in Beijing adults. The risk of CAC escalates with more MetS components, including elevated blood pressure and hyperglycemia.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Limited data exists on metabolic syndrome (MetS) influence on coronary artery calcification (CAC) in China.
- Investigating CAC distribution and MetS impact in a Beijing community is crucial.
Purpose of the Study:
- To explore CAC distribution in individuals with and without MetS.
- To estimate the influence of MetS and its components on CAC in a Beijing population.
Main Methods:
- 1647 Beijing residents (age 40-77) underwent cardiovascular risk assessment.
- Fasting plasma glucose (FPG), blood lipids, and 64-MDCT coronary artery calcium score (CACS) were measured.
Main Results:
- CAC prevalence and extent increased with age, higher in MetS subjects (except >65 yrs).
- Risk of CAC rose with more MetS components (ORs 1.60-3.12).
- Elevated blood pressure (OR 2.64), FPG (OR 1.67), triglycerides (OR 1.32), and overweight (OR 1.37) increased CAC risk.
Conclusions:
- MetS elevates CAC risk in the Beijing community.
- CAC risk is associated with the number and variety of MetS components.
- Elevated blood pressure, hyperglycemia, hypertriglyceridemia, and overweight are key contributors to CAC risk.
Background:
Little is known about the influence of metabolic syndrome (MetS) on coronary artery calcification (CAC) in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing.
Methods:
A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose (FPG), blood lipids, and 64 multi-detector computed tomography (64-MDCT) coronary artery calcium score (CACS) measurement (Agatston scoring). The distribution of CAC was described, and the influence of MetS components on CAC was evaluated.
Results:
In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects (all P < 0.05), with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and = 4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively (all P < 0.05). Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively (all P < 0.05).
Conclusions:
In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.
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