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Upregulation of glucosylceramide synthase protein in papillary thyroid carcinoma

Ke Zhang1, Ying-Hua Song2, Xiao-Yan Lin3

  • 1Department of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

Chinese Medical Journal
|December 18, 2013
PubMed
Abstract

Insights

Glucosylceramide synthase (GCS) is overexpressed in papillary thyroid cancer (PTC), correlating with tumor progression. This suggests GCS may be a prognostic factor for PTC patients.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Glucosylceramide synthase (GCS) reduces ceramide levels, potentially contributing to multidrug resistance (MDR) by inhibiting apoptosis.
  • The role and clinical significance of GCS in thyroid neoplasms, particularly papillary thyroid carcinomas (PTCs), are not well understood.

Purpose of the Study:

  • To investigate the expression of GCS in papillary thyroid carcinomas (PTCs).
  • To explore the correlation between GCS expression and clinicopathological characteristics in PTC patients.

Main Methods:

  • Retrospective analysis of GCS protein expression in 108 PTC patient tissue specimens.
  • Immunohistochemistry and Western blotting were employed to quantify GCS levels.

Main Results:

  • GCS was frequently overexpressed in PTC cells compared to normal follicular cells.
  • GCS overexpression was significantly associated with larger primary tumor size, local invasion, lymph node metastasis, and local recurrence.
  • No association was found between GCS expression and gender, age, pathological variants, tumor multifocality, overall tumor stage, or distant metastasis.

Conclusions:

  • Glucosylceramide synthase (GCS) is upregulated in papillary thyroid carcinomas (PTCs).
  • GCS may serve as an independent prognostic factor for predicting outcomes in PTC patients.

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