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Association between C-reactive protein gene +1059 G/C polymorphism and the risk of coronary heart disease: a

Cong-Sheng Li1, Bi-Rong Guo2, Zeng Guo3

  • 1Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China.

Chinese Medical Journal
|December 18, 2013
PubMed

Insights

The C-reactive protein (CRP) gene +1059 G/C polymorphism shows no overall link to coronary heart disease (CHD) risk. However, a significant association with increased CHD risk was found specifically among Caucasians.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • The association between the C-reactive protein (CRP) gene +1059 G/C polymorphism and coronary heart disease (CHD) risk is debated.
  • Previous studies have yielded inconclusive results, necessitating further investigation.

Purpose of the Study:

  • To clarify the association between the CRP gene +1059 G/C polymorphism and CHD risk.
  • To analyze potential ethnic differences in this association.

Main Methods:

  • A comprehensive meta-analysis of case-control studies was performed.
  • Studies were selected based on predefined inclusion criteria.
  • Statistical analysis used odds ratios (OR) and 95% confidence intervals (CI), with publication bias assessed via Begg's funnel plot and Egger's regression test.

Main Results:

  • The overall meta-analysis of 13 studies (6316 cases, 4467 controls) found no significant association between the CRP gene +1059 G/C polymorphism and CHD risk.
  • Subgroup analysis by ethnicity revealed a significant association between the CRP gene +1059 G/C polymorphism and increased CHD risk among Caucasians.
  • No significant association was observed among Asians and Africans.

Conclusions:

  • The CRP gene +1059 G/C polymorphism may be associated with an elevated risk of CHD in Caucasian populations.
  • Further research is required to validate these findings and elucidate the underlying mechanisms.
Abstract

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