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Updated: May 4, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
Multi-level and multi-scale integrative approach to the understanding of human blastocyst implantation
Jayasree Sengupta1, Debabrata Ghosh2
1Department of Physiology, North DMC Medical College, Hindu Rao Hospital, Delhi 110007, India.
Abstract:
Implantation is a complex process which results in fixation of zona pellucida free blastocyst to the maternal uterine endometrium. In the human, it involves progesterone mediated preparation of endometrium, age- and stage-matched development of pre-implantation embryo, and interaction between embryo and endometrium. In the present essay, we present the case to explain why there is a necessity of undertaking multi-level, multi-scale integrative approach to deconstruct the succession process of endometrial development to the climax of implantation.
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