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Related Experiment Videos

Morphologic mast cell cycles.

A M Dvorak, R P Schleimer, L M Lichtenstein

    Cellular Immunology
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Human mast cells exhibit dynamic morphologic cycles during anaphylactic degranulation and recovery. These cells transform into lymphocyte-like states before regenerating granules, similar to lymphocyte cycles.

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Mast cells are key players in allergic reactions, releasing histamine and granules.
    • Understanding mast cell degranulation and recovery is crucial for allergy research.

    Purpose of the Study:

    • To investigate the ultrastructural changes and morphologic cycles of human mast cells during and after degranulation.
    • To compare mast cell morphologic changes with those of lymphocytes.

    Main Methods:

    • Isolated, partially purified, cultured human lung mast cells were stimulated with anti-IgE.
    • Ultrastructural studies were performed during early degranulation and recovery phases.

    Main Results:

    • Mast cells undergo morphologic cycles, transitioning to small, lymphocyte-like cells after degranulation.

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  • These cells then undergo blast transformation, developing into larger, immature mast cells with regenerating granules.
  • The observed cycle shares similarities with lymphocyte morphologic cycles.

    • Conclusions:

    • Human mast cells possess a remarkable capacity for morphologic regeneration following degranulation.
    • These findings provide insights into mast cell plasticity and recovery mechanisms.