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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrin containing biodegradable particles: from preparation to drug delivery applications
Nadiah Zafar1, Hatem Fessi1, Abdelhamid Elaissari1
1University of Lyon, F-69622, Lyon, University Lyon-1, CNRS, UMR 5007, LAGEP-CPE, 43 bd 11 Novembre 1918, F-69622 Villeurbanne, France.
International Journal of Pharmaceutics
|December 18, 2013
Summary
Cyclodextrins (CDs) are versatile cyclic oligosaccharides with unique structures for drug delivery. This review explores their applications and formulation techniques in advanced CD-based nanocarriers.
Area of Science:
- Biochemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch.
- They possess a hydrophobic cavity and hydrophilic exterior, enabling supramolecular complexation.
- CDs are structurally similar to calixarenes, cyclophanes, and crown ethers.
Purpose of the Study:
- To review the diverse applications of cyclodextrins in drug delivery.
- To highlight novel multifunctional CD-based nanocarriers and formulation techniques.
- To discuss the molecular structure, complexation properties, and nanosystem integration of CDs.
Main Methods:
- Literature review of cyclodextrin applications in drug delivery.
- Analysis of molecular structure and complexation behavior of CDs.
- Exploration of CD integration into various nanosystems.
Main Results:
- CDs are effective in forming inclusion complexes without covalent bonds.
- Multifunctional CD-based nanocarriers show promise in diverse drug delivery applications.
- CDs can be incorporated into liposomes, magnetic nanoparticles, polymers, and micro/nanospheres.
Conclusions:
- Cyclodextrins are highly adaptable excipients for advanced drug delivery systems.
- The unique properties of CDs facilitate the development of innovative nanocarriers.
- Further research into CD-based nanosystems can significantly advance pharmaceutical formulations.
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