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Microbiome of the Eye01:22

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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
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Atopic keratoconjunctivitis: A review.

Joseph J Chen1, Danielle S Applebaum2, Grace S Sun2

  • 1Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.

Journal of the American Academy of Dermatology
|December 18, 2013
PubMed
Summary
This summary is machine-generated.

Atopic keratoconjunctivitis, an eye condition linked to atopic dermatitis, demands prompt treatment to prevent vision loss. Management involves ophthalmologist collaboration and various medications to control inflammation and complications.

Keywords:
atopic dermatitisatopic keratoconjunctivitisconjunctivacorneakeratoconusocularsight threatening

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Immunology

Background:

  • Atopic keratoconjunctivitis (AKC) is a severe, chronic, non-infectious inflammatory eye condition.
  • It is a significant ophthalmic complication of atopic dermatitis, potentially leading to irreversible vision impairment.
  • AKC can lead to serious complications including cataracts, keratoconus, infectious keratitis, blepharitis, and glaucoma.

Purpose of the Study:

  • To highlight the critical nature of atopic keratoconjunctivitis and its association with atopic dermatitis.
  • To emphasize the necessity of prompt and effective management to prevent vision loss.
  • To outline current treatment strategies and indications for specialist referral.

Main Methods:

  • Review of existing literature on atopic keratoconjunctivitis and its management.
  • Identification of common complications associated with the condition.
  • Summary of recommended pharmacological treatment options.

Main Results:

  • Atopic keratoconjunctivitis presents a high risk for vision-threatening complications if not treated promptly.
  • Effective management requires a multidisciplinary approach, often involving ophthalmologists.
  • Treatment regimens typically combine multiple drug classes to address inflammation and associated symptoms.

Conclusions:

  • Early and aggressive management of atopic keratoconjunctivitis is crucial for preserving vision.
  • Collaboration between dermatologists and ophthalmologists is essential for optimal patient outcomes.
  • A combination of mast cell inhibitors, antihistamines, corticosteroids, and calcineurin inhibitors forms the cornerstone of AKC treatment.