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818
Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds
Anne Eskes1, Hester Vermeulen, Cees Lucas
1Quality Assurance & Process Innovation, Academic Medical Centre, University of Amsterdam & Amsterdam School of Health Professions, Meibergdreef 9, Amsterdam, Netherlands, 1105AZ.
The Cochrane Database of Systematic Reviews
|December 18, 2013
Summary
Hyperbaric oxygen therapy (HBOT) may improve outcomes for skin grafting and trauma wounds, but evidence is limited. More high-quality research is needed to confirm the effects of HBOT on wound healing.
Area of Science:
- Wound healing research
- Hyperbaric medicine
Background:
- Hyperbaric oxygen therapy (HBOT) is a treatment for acute wounds from surgery and trauma.
- The precise impact of HBOT on wound healing remains uncertain.
Purpose of the Study:
- To evaluate the effects of HBOT on the healing process of acute surgical and traumatic wounds.
Main Methods:
- A systematic review of randomized controlled trials (RCTs) was conducted.
- Searches included major databases like Cochrane, MEDLINE, EMBASE, and CINAHL up to August 2013.
- Four trials with 229 participants were included, comparing HBOT with various interventions or sham treatments.
Main Results:
- One trial indicated significantly higher graft survival with HBOT for burn wounds.
- Another trial showed improved wound healing and reduced tissue necrosis in crush injuries with HBOT.
- However, results were heterogeneous, and all trials had unclear or high risk of bias, precluding meta-analysis.
Conclusions:
- High-quality evidence on HBOT's effects on wound healing is lacking.
- While some small trials suggest potential benefits for skin grafting and trauma, their risk of bias necessitates caution.
- Further rigorous RCTs are essential to ascertain the efficacy of HBOT in wound care.
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