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Related Experiment Videos

Elevated intravesicular fluid thyroid-stimulating hormone concentration in hydatidiform mole.

R Gunasegaram, K L Peh, A Loganath

    International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
    |June 1, 1986
    PubMed
    Summary

    Hyperthyroidism in hydatidiform mole may be caused by thyroid-stimulating hormone (TSH) found in molar tissue. This TSH is immunologically similar to pituitary TSH, distinct from hCG.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Gynecology

    Background:

    • Hydatidiform mole is a pregnancy complication associated with gestational trophoblastic disease.
    • Hyperthyroidism can occur in patients with hydatidiform mole, but the exact mechanism is not fully understood.

    Purpose of the Study:

    • To investigate the potential role of thyroid-stimulating hormone (TSH) in the development of hyperthyroidism associated with hydatidiform mole.
    • To measure concentrations of TSH and human chorionic gonadotropin (beta-hCG) in the serous fluid of patients with hydatidiform mole.

    Main Methods:

    • Measurement of immunoreactive TSH and beta-hCG concentrations.
    • Analysis of serous fluid samples from 43 patients with hydatidiform mole (aged 15-45 years, amenorrhea 11-31 weeks).

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    Main Results:

    • Elevated concentrations of both TSH and beta-hCG were detected in all tested serous fluid samples.
    • The identified TSH was immunologically similar to pituitary TSH but distinct from hCG and luteinizing hormone (LH).

    Conclusions:

    • The study suggests that TSH found within hydatidiform mole tissue may contribute to hyperthyroidism.
    • This molar TSH is likely responsible for the observed thyroid dysfunction, separate from the effects of beta-hCG.