Related Experiment Video
Updated: May 4, 2026
11:47
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
2.1K
Study on hyperuricemia in HBV-associated glomerulonephritis.
Yongze Zhuang1, Yinghao Yu, Yingfang Huang
1Dept of Nephrology, Fuzhou General Hospital of Nanjing Military Command, 156 Xier'Huan N Rd, Fuzhou, Fujian 350025, China; zhuangyongze@126.com.
American Journal of Clinical Pathology
|December 18, 2013
Summary
Hyperuricemia is common in hepatitis B virus-associated glomerulonephritis (HBV-GN), affecting 31.3% of patients. Elevated serum creatinine and tubular interstitial injury are key risk factors, potentially worsening kidney disease and causing hypertension.
Area of Science:
- Nephrology
- Virology
- Internal Medicine
Background:
- Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a significant cause of kidney disease.
- Hyperuricemia is increasingly recognized as a potential contributor to kidney damage.
Purpose of the Study:
- To investigate the prevalence of hyperuricemia in patients with HBV-GN.
- To identify the clinical and pathological risk factors associated with hyperuricemia in this population.
Main Methods:
- Retrospective analysis of 227 HBV-GN cases.
- Univariate and multivariate logistic regression to determine risk factors for hyperuricemia.
- Comparison of clinical and pathological data between hyperuricemic and normouricemic HBV-GN patients.
Main Results:
- 31.3% of HBV-GN patients presented with hyperuricemia at renal biopsy.
- Serum creatinine levels and severity of tubular interstitial injury were independent risk factors for hyperuricemia.
- Hyperuricemic patients showed higher rates of hypertension, lower eGFR, and distinct histopathological features (less membranous nephropathy, more proliferative sclerosing glomerulonephritis).
Conclusions:
- Hyperuricemia is a prevalent condition in HBV-GN.
- Hyperuricemia may accelerate HBV-GN progression and renal tubular interstitial injury.
- Hyperuricemia is associated with an increased risk of developing hypertension in HBV-GN patients.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
842
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
842
01:25Jaundice
35
Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
35
01:29Urine Studies I: Urinalysis
2.6K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
2.6K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
559
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
01:28Viral Hepatitis I: Introduction
25
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
01:24Serum Studies: Renal Function Tests
688
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
688