Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

90
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

219
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
219
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

143
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
143
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.0K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.0K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
Mismatch Repair01:36

Mismatch Repair

38.1K
Overview
38.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistance to novel β-lactam/β-lactamase inhibitors among carbapenem-resistant <i>Pseudomonas aeruginosa</i> and clinical implications in the prospective observational <i>Pseudomonas</i> study.

Antimicrobial agents and chemotherapy·2026
Same author

Clinical Characteristics and Outcomes of Bloodstream Infections Caused by Metallo-β-Lactamase-Producing Enterobacterales in Argentina: A Subanalysis of the EMBARCAR Prospective Multicenter Cohort Study.

Open forum infectious diseases·2026
Same author

Carbapenem-Resistant Gram-Negative Bacilli Bacteremia in Argentina (EMBARCAR): Findings From a Prospective, Multicenter Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens.

Antimicrobial agents and chemotherapy·2024
Same author

Ceftobiprole for Treatment of Complicated <i>Staphylococcus aureus</i> Bacteremia.

The New England journal of medicine·2023
Same author

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2023
Same journal

Anticalcitonin: Limited utility of a context-dependent biomarker demonstrated in another real-world data set.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Procalcitonin Testing in Community-Acquired Pneumonia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Wanted: A Relevant Correlate of Protection for Dengue Vaccines.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Low Post-Treatment Recurrence After a Shortened All-oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals without Prior Second-Line Drug Exposure in Kazakhstan.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Sepsis Diagnostic Excellence and its Association with Mortality in Adults with Potential Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K

Methicillin-resistant Staphylococcus aureus: an evolving pathogen.

Martin E Stryjewski1, G Ralph Corey

  • 1Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno" (CEMIC), Buenos Aires, Argentina.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 18, 2013
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus aureus (MRSA) remains a threat due to rising resistance to antibiotics like vancomycin. New resistance mechanisms for newer drugs like linezolid also necessitate novel antimicrobial therapies.

More Related Videos

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

24.3K
Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.3K

Related Experiment Videos

Last Updated: May 4, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

24.3K
Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.3K

Area of Science:

  • Microbiology and Infectious Diseases
  • Clinical Pharmacy and Pharmacology
  • Epidemiology of Antimicrobial Resistance

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global challenge in treating serious infections.
  • Despite infection control efforts, MRSA remains a prevalent pathogen.
  • Emerging resistance to vancomycin and newer antibiotics like linezolid and daptomycin is a growing concern.

Purpose of the Study:

  • To review the current landscape of antimicrobial resistance in MRSA.
  • To highlight the challenges posed by horizontal transmission of resistance genes.
  • To underscore the urgent need for novel antimicrobial agents.

Main Methods:

  • Review of current scientific literature on MRSA epidemiology and resistance trends.
  • Analysis of resistance mechanisms, including heteroresistance and specific gene mutations (e.g., cfr).
  • Examination of clinical data regarding treatment outcomes and emerging resistance patterns.

Main Results:

  • Increasing minimum inhibitory concentrations (MICs) and emergence of vancomycin-intermediate and resistant MRSA strains.
  • Reported point mutations conferring linezolid resistance and horizontal transmission of cfr-mediated resistance.
  • While daptomycin and linezolid resistance remain low, these trends indicate a need for vigilance.

Conclusions:

  • The evolving resistance patterns of MRSA, including to newer therapies, necessitate continuous monitoring.
  • Horizontal gene transfer plays a crucial role in the spread of MRSA resistance.
  • There is an ongoing and critical need for the development of new, effective antimicrobial drugs to combat resistant MRSA infections.