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Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Tissue engineering in periodontal tissue.

Takanori Iwata¹, Masayuki Yamato, Isao Ishikawa

¹Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.

Anatomical Record (Hoboken, N.J. : 2007)

|December 18, 2013

Summary

Periodontal regeneration aims to restore lost bone and tissues caused by periodontitis. Tissue engineering, combining cells, growth factors, and scaffolds, shows promise for advanced periodontal repair.

Keywords:

bone cementum clinical trials cytotherapy periodontal ligament periodontal regeneration periodontal tissue stem cells

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Last Updated: May 4, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

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Published on: April 3, 2018

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Area of Science:

Periodontal medicine
Regenerative dentistry
Biomaterials science

Background:

Periodontitis is a global bacterial infection causing irreversible periodontal tissue and alveolar bone loss.
Current treatments for periodontitis have limited regenerative outcomes.
Periodontal regeneration involves reconstructing the entire attachment apparatus, including bone, cementum, and ligament.

Purpose of the Study:

To review recent advancements in tissue engineering for periodontal regeneration.
To discuss the potential of tissue engineering strategies in overcoming limitations of current treatments.
To explore future perspectives in the field of periodontal regeneration.

Main Methods:

Focus on combination treatments involving cells, growth factors, and scaffolds.
Analysis of studies conducted in experimental animal models.
Review of clinical trials translating tissue engineering concepts.

Main Results:

Tissue engineering approaches are being investigated to achieve complete periodontal regeneration.
Combination therapies show potential in preclinical studies and early clinical trials.
Progress has been made in developing strategies for reconstructing hard and soft periodontal tissues.

Conclusions:

Tissue engineering offers a promising avenue for true periodontal regeneration.
Further research and clinical translation are needed to optimize these advanced therapies.
The future of periodontal regeneration lies in innovative tissue engineering solutions.