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Related Experiment Video

Updated: May 4, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Cell sheet-based cardiac tissue engineering.

Katsuhisa Matsuura1, Shinako Masuda, Tatsuya Shimizu

  • 1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, Japan; Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, Japan.

Anatomical Record (Hoboken, N.J. : 2007)
|December 18, 2013
PubMed
Summary
This summary is machine-generated.

Cell sheet engineering advances cardiac tissue regeneration for heart disease treatment. Innovations in layering and large-scale stem cell cultivation enable thicker tissues for transplantation and disease modeling.

Keywords:
bioreactorcardiac tissue engineeringcell sheetpluripotent stem cellsvascularization

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Cardiovascular Research

Background:

  • Tissue engineering is crucial for regenerative medicine and creating disease models.
  • Cell sheet-based methods are a promising strategy in cardiac tissue engineering.
  • Cell sheet transplantation has been used to treat heart diseases, improving cardiac function and heart failure symptoms.

Purpose of the Study:

  • To highlight the advancements in cell sheet-based cardiac tissue engineering.
  • To discuss the potential of fabricating thickened human cardiac tissue for transplantation and disease modeling.

Main Methods:

  • Utilizing cell sheet transplantation for cardiac repair.
  • Developing technologies for layering cardiac cell sheets with vascularization.
  • Establishing large-scale cultivation systems for embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Main Results:

  • Cell sheet transplantation has demonstrated efficacy in ameliorating cardiac dysfunction.
  • Progress in layering techniques and vascularization is enabling the creation of more complex cardiac tissues.
  • Large-scale stem cell cultivation is paving the way for clinical applications.

Conclusions:

  • Advancements in cell sheet engineering, vascularization, and stem cell technology are enabling the fabrication of functional, thickened cardiac tissues.
  • These developments hold significant promise for both cardiac tissue transplantation and the creation of sophisticated in vitro cardiac models for research.