Related Experiment Video
Updated: Feb 12, 2026
05:51
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
Published on: April 12, 2021
4.7K
Functional tissue engineering of the liver and islets
1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjyuku-ku, Tokyo, Japan; Department of Gastroenterological Surgery, Tokyo Women's Medical University, Shinjyuku-ku, Tokyo, Japan.
Anatomical Record (Hoboken, N.J. : 2007)
|December 18, 2013
Summary
Cell-based therapies using hepatocytes and islets show promise for liver diseases and diabetes. Strategies to improve cell survival are crucial for creating functional engineered tissues in vivo.
Area of Science:
- Regenerative Medicine
- Hepatology
- Endocrinology
Background:
- Cell-based therapies using hepatocytes and islets are emerging treatments for liver diseases and diabetes mellitus.
- Current clinical trials often involve cell delivery via the portal circulation.
- Tissue engineering approaches aim to create functional tissues in vivo for enhanced therapeutic effects.
Purpose of the Study:
- To review strategies for improving cell survival in engineered liver and islet tissues.
- To highlight methods for achieving higher cell engraftment and sustained therapeutic effects.
Main Methods:
- Review of recent clinical trials and tissue engineering approaches.
- Analysis of strategies focused on cell survival and tissue maintenance.
Main Results:
- Cell-based therapies show potential for treating liver diseases and diabetes.
- Tissue engineering offers a promising in vivo approach for functional tissue creation.
- Optimizing cell survival is key to the success of these regenerative strategies.
Conclusions:
- Improving cell survival is critical for the efficacy of engineered liver and islet tissues.
- Advanced strategies are needed to sustain engineered tissues and their therapeutic benefits.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
208
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
208
01:23Epithelial Tissues and Their Functions
41.2K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
Epithelial tissues provide the body's first line of protection from physical,...
41.2K
01:17Functions of Connective Tissues
17.1K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
17.1K
00:49What is Genetic Engineering?
80.4K
Overview
80.4K
01:27Liver Histology
4.5K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
4.5K
01:30Liver Physiology
3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K