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Related Experiment Video

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Bronchoalveolar Lavage BAL for Research; Obtaining Adequate Sample Yield
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7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial.

Jonathan D Jacobs1, Megan Foster, Jim Wan

  • 1Division of Emergency Medicine, Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, TN 38103. jay.pershad@mlh.org.

Pediatrics
|December 18, 2013
PubMed
Summary
This summary is machine-generated.

Seven percent hypertonic saline (HS) did not significantly improve bronchiolitis severity scores in infants compared to standard saline. This study found no significant differences in hospitalization or length of stay for acute bronchiolitis treatment.

Keywords:
7% hypertonic salineacute bronchiolitis

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Area of Science:

  • Pediatric Emergency Medicine
  • Respiratory Medicine
  • Clinical Trials

Background:

  • Hypertonic saline (HS) may enhance mucus clearance in infants with acute bronchiolitis.
  • Higher HS concentrations (3-5%) show a trend towards improved outcomes compared to 0.9% saline with epinephrine.
  • The efficacy of 7% HS in acute bronchiolitis has not been previously studied.

Purpose of the Study:

  • To evaluate the effectiveness of 7% HS compared to 0.9% saline with epinephrine in infants with moderate to severe acute bronchiolitis.
  • To assess the impact on bronchiolitis severity score (BSS), hospitalization rates, and length of stay.

Main Methods:

  • Prospective, double-blind, randomized controlled trial involving 101 infants with acute bronchiolitis.
  • Interventions: nebulized 7% HS or 0.9% saline, both with epinephrine.
  • Primary outcome: change in BSS; Secondary outcomes: hospitalization rate, discharge timing, and length of stay (ED and inpatient).

Main Results:

  • No statistically significant difference in the mean decrease of BSS between the 7% HS and control groups (2.6 vs 2.4).
  • Similar rates of hospitalization (42% vs 49%), ED/inpatient length of stay, and early discharge (at 23 hours) between the groups.

Conclusions:

  • In moderate to severe acute bronchiolitis, 7% HS with epinephrine does not provide a clinically significant reduction in BSS compared to 0.9% saline with epinephrine.
  • The use of 7% HS did not demonstrate significant benefits regarding hospitalization or length of stay in this patient population.