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Propanil-induced histopathological changes in the liver and kidney of mice
1Zoology Section, Biology Department, Science Faculty, Ege University, Bornova-Izmir, Turkey. ozlem.cakici@ege.edu.tr
Objective:
To examine sublethal toxic effects of propanil on liver and kidney of albino Swiss mice, Mus musculus.
Study Design:
Different doses of propanil (75, 150, and 300 mg/kg) were administered to determine histologic defects on liver and kidney tissues of mice for 30 consecutive days. Biometric analyses (area measurements of hepatocyte/nucleus and glomerulus/renal corpuscle) were also conducted to determine whether there were statistical differences in these end points.
Results:
Cloudy swelling, cytoplasmic vacuolization, nuclear degeneration, nucleus loss, mononuclear cell infiltration, congestion, enlargement of the sinusoids, and increases in the number of Kupffer cells were prominent in the liver of exposed mice. In kidney tissue mononuclear cell infiltration, glomerular degeneration, glomerular loss, and congestion were determined in propanil-treated groups.
Conclusion:
Propanil induced dose-dependent histopathological changes in the liver and kidney tissues of exposed mice. This study showed that propanil exposure might cause harmful effects to nontarget organisms, including humans.
Insights
Propanil herbicide causes dose-dependent liver and kidney damage in mice. This study highlights potential risks of propanil exposure to non-target organisms, including humans.
Area of Science:
- Toxicology
- Histopathology
- Environmental Health
Background:
- Propanil is a widely used herbicide.
- Sublethal effects of propanil on mammalian organs require further investigation.
Purpose of the Study:
- To assess the sublethal toxic effects of propanil on the liver and kidney of albino Swiss mice.
- To determine dose-dependent histopathological alterations and biometric changes.
Main Methods:
- Mice were administered varying doses of propanil (75, 150, 300 mg/kg) for 30 days.
- Histological examination of liver and kidney tissues was performed.
- Biometric analyses of hepatocytes, nuclei, glomeruli, and renal corpuscles were conducted.
Main Results:
- Propanil induced significant histopathological changes in the liver, including cloudy swelling, cytoplasmic vacuolization, nuclear degeneration, and increased Kupffer cells.
- Kidney tissues showed mononuclear cell infiltration, glomerular degeneration, and congestion.
- Dose-dependent alterations were observed in both organs.
Conclusions:
- Propanil exposure results in dose-dependent histopathological damage to the liver and kidney in mice.
- The findings suggest potential harmful effects of propanil on non-target organisms, including humans.
