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Assessing medication adherence in solid-organ transplant recipients.

Gloria Chun-Wei Su1, Erica D Greanya, Nilufar Partovi

  • 1Lower Mainland Pharmacy Services, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|December 19, 2013
PubMed
Summary

Immunosuppressant medication adherence was high in lung, kidney, and liver transplant recipients, with over 90% medication possession ratio. Further research is needed to identify factors optimizing adherence in high-risk patients.

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Area of Science:

  • Transplant medicine
  • Pharmacology
  • Patient adherence

Background:

  • Nonadherence to immunosuppressants can lead to graft rejection in transplant recipients.
  • Understanding adherence rates and risk factors is crucial for long-term transplant success.

Purpose of the Study:

  • To determine and compare nonadherence prevalence in lung, kidney, and liver transplant recipients.
  • To identify potential risk factors associated with nonadherence to immunosuppressants.

Main Methods:

  • A retrospective cohort study of 225 outpatients across lung, kidney, and liver transplant programs.
  • Medication possession ratio (MPR) and prescription refill gaps were used as adherence markers over two years.
  • Adherence was defined as an MPR of 80% or higher.

Main Results:

  • High adherence rates were observed across all cohorts: lung (95.4% ± 7.5%), kidney (95.9% ± 7.6%), and liver (92.7% ± 12.3%).
  • Only 7.1% of patients fell below the 80% MPR threshold for nonadherence.
  • The low number of nonadherent patients precluded statistical analysis of risk factors.

Conclusions:

  • Immunosuppressant medication adherence is high in lung, kidney, and liver transplant recipients at this center.
  • Further investigation is required to assess long-term adherence trends and identify factors that optimize adherence in at-risk populations.