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Updated: May 4, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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Are selective estrogen receptor modulators (SERMs) a therapeutic option for HPV-associated cervical lesions and

Karl Munger1

  • 1Division of Infectious Diseases, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts.

The American Journal of Pathology
|December 19, 2013
PubMed

Insights

This commentary discusses raloxifene, an oral selective estrogen receptor modulator (SERM), as a potential treatment for human papillomavirus (HPV)-associated cancers. Research evaluates its efficacy in combating these challenging malignancies.

Area of Science:

  • Oncology
  • Virology
  • Pharmacology

Background:

  • Human papillomavirus (HPV) is a major cause of various cancers.
  • Current treatments for HPV-associated cancers have limitations.
  • Selective estrogen receptor modulators (SERMs) are being explored for novel therapeutic applications.

Purpose of the Study:

  • To highlight research evaluating the oral SERM raloxifene.
  • To assess the potential of raloxifene as a therapeutic agent for HPV-associated cancers.

Main Methods:

  • Commentary on existing research by Spurgeon et al.
  • Evaluation of raloxifene's mechanism of action and preclinical data.
  • Review of potential clinical applications.

Main Results:

  • Raloxifene shows promise as a therapeutic agent.
  • The study by Spurgeon et al. provides a basis for further investigation.
  • Further research is warranted to confirm efficacy and safety.

Conclusions:

  • Raloxifene is a potential candidate for treating HPV-associated cancers.
  • Further clinical trials are needed to establish raloxifene's role in cancer therapy.
  • Targeting estrogen receptor pathways may offer new avenues for HPV cancer treatment.

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