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Related Experiment Videos

Subcutaneous Whipple's disease.

D Kwee, J P Fields, L E King

    Journal of the American Academy of Dermatology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Cutaneous findings in Whipple's disease are uncommon but can be characteristic. Skin biopsy of subcutaneous nodules can help diagnose Whipple's disease.

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    What causes alopecia areata?

    Experimental dermatology·2013

    Area of Science:

    • Dermatology
    • Infectious Diseases
    • Pathology

    Background:

    • Whipple's disease is a rare systemic bacterial infection caused by Tropheryma whipplei.
    • Cutaneous manifestations of Whipple's disease are infrequent and typically present as nonspecific lesions.

    Observation:

    • A 37-year-old male with known Whipple's disease presented with soft, subcutaneous nodules on his face, neck, and limbs.
    • These nodules represented a form of panniculitis.

    Findings:

    • Skin biopsy revealed nonspecific panniculitis with characteristic intracellular inclusions.
    • Periodic acid-Schiff staining confirmed inclusions typical of Tropheryma whipplei.

    Implications:

    • This case highlights that specific cutaneous findings can occur in Whipple's disease.
  • Skin biopsy is a valuable diagnostic tool for identifying characteristic Whipple's disease inclusions in patients with subcutaneous nodules.