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Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase

Jeroen van Ameijde1, Addy P R Zwiebel1, Rob Ruijtenbeek2

  • 1Medicinal Chemistry and Chemical Biology, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.

Bioorganic & Medicinal Chemistry Letters
|December 19, 2013
PubMed

Keywords:
Bisubstrate based inhibitorEnzyme inhibitorHistone acetyltransferasePosttranslational modificationProtein acetylation

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